TOXICOLOGICAL RISK ASSESSMENT TRAINING PROGRAMME
Wednesday, 8 July
Training: Risk assessment and contaminants (OE1 and OE3)
INSP (National Institute of Public Health) meeting room
Thursday, 9 July
Training: Risk assessment and contaminants (continued) INSP
INSP (National Institute of Public Health) meeting room
TOXICOLOGICAL RISK ASSESSMENT TRAINING PROGRAMME
1. Risk analysis.
1.1 Introduction
2. – Fundamentals of risk assessment.
2.1 General concepts.
Toxicity.
Risk vs hazard.
Factors affecting toxicity.
Uncertainty and variability.
Dose-effect and dose-response relationships.
2.2 Risk assessment model.
Determination of hazard.
Analysis of contaminants.
Characterisation of hazard.
Exposure assessment.
Models.
Estimation.
Strategies for estimating human exposure.
Risk characterisation.
Assessment of toxic effects in humans. NOEL..
NOAEL, IDA, IDE, IDR, TWI, HQ, BMDL…
Special case. Carcinogenic and mutagenic substances.
Safety margin. Exposure margin (MOS). MOE
2.3. Practical exercises
Practical Exercise 1. Calculation of IDA/IST
Practical Exercise 2. Estimated daily intake
Practical Exercise 3. MOE/MoS
3. International organisations.
3.1. Types of organisations
WHO, EFSA, EPA, IOM, AESAN…
3.2. Actual risk assessment carried out by an agency (e.g. glyphosate)
4. Practical module. Risk assessment.
Practical exercises.
Cadmium in cereals
Mercury in fish.
PRIMo pesticides.
Fluoride in water.
5. Risk management
Legislation and recommendations.
6. Communicating toxic risk
6.1 How do we communicate risk?
